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High blood pressure affects 25% of adults in western societies and is the major cause of heart attacks, strokes and kidney failure. It is genetically determined and elucidation of the causative genes and biological mechanisms responsible for high blood pressure will have a profound bearing on new methods of detection, prevention and treatment of common diseases of the heart and blood vessels.

This proposal is a collaboration between 5 large research groupings with major expertise in linking gene to function in the context of heart disease. We plan to use our unique experimental models to help to dissect genes responsible for the same disease patterns in humans. We shall utilise state of the art and beyond methods including studies on gene expression and the use of single nucleotide polymorphisms (SNPs) to discover genes and pathways responsible for disease processes. Our plan includes a systematic and novel combination of studies in rodent models of cardiovascular disease, which will then inform studies in large groups of patients with disease and normal subjects to discover new robust candidate genes responsible for high blood pressure and its complications. This Consortium will make UK research internationally competitive in cardiovascular functional genomics.

Maturity: Initial Research
Region: UK
Type: Other
Grant Value:
Start Date: 01/09/2003
End Date: Not specified
Project Status: funded
Funding Agency: Wellcome

Project Members
Prof Malcolm Atkinson
Dr Ela Hunt
Prof David Gilbert

Collaborating Organisations
Bioinformatics Research Centre (University of Glasgow)
Department of Computing Science (University of Glasgow)
Imperial College London
School of Biological Sciences (University of Edinburgh)
University of Leicester
University of Oxford

Component(s) Project Develops
This project is not associated with any components at present.

Application Area(s) associated with Project
This project is not associated with any application areas at present.


Last Updated: 22 Jun 12 11:02
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