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eScience Pilot Project in Integrative Biology

Integrative Biology

The goal of the proposed pilot project is to build a Grid-enabled development platform for integrative biological modelling. The project will build upon existing e-Science activities both within Oxford and throughout the UK to support life scientists in moving on to the next grand challenge: that of determining biological function from the wealth of biological data that is now available. The project will develop: grid-enabled generic and standardised modelling and simulation tools allowing assimilation and synthesis of data for use in model development and parameter estimation; a robust and fault-tolerant Grid infrastructure; and tools to allow seamless integration of HPC, cluster computing, distributed databases, computational steering, performance control, and visualisation of complex simulated data, in the biology domain. The platform will allow clinicians and biologists to perform in-silico testing and development of novel experimental approaches, concentrating in this development phase on two major disease areas: cardiovascular disease and cancer. In cancer, it will be possible to grow virtual tumours, through the crucial stages of early development. In whole­heart modelling the clinician will be able to explore in-silico the likely causes of commonly occurring heart conditions. For both disease areas, it will be possible to test the actions of new drugs, and design and optimise alternative treatment protocols such as multiple-drug therapies, supporting the drive towards patient-centred care regimes. The project will be undertaken by a consortium comprising experimental, clinical, modelling and computational groups at seven Universities: Oxford, Nottingham, Auckland, Birmingham, Leeds, UCL, and Sheffield. These are complemented by strong involvement from CCLRC and IBM.

Maturity: Initial Research
Region: UK
Type: Pilot
Grant Value: £2,437,814.00
Start Date: 01/02/2004
End Date: Not specified
Project Status: funded
Funding Agency: EPSRC


Project Members
There are currently no Project Members associated with this project.


Collaborating Organisations
IBM
University College London
University of Auckland
University of Birmingham
University of Leeds
University of Nottingham
University of Oxford
University of Sheffield


Component(s) Project Develops
This project is not associated with any components at present.


Application Area(s) associated with Project
This project is not associated with any application areas at present.

 

Last Updated: 22 Jun 12 11:02
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