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BPS: A Software Tool for the Simulation and Analysis of Biochemical Networks



The aim of this interdisciplinary project is to model diverse biochemical networks and develop an associated computational system to facilitate the analysis of the behaviour of these networks. Biochemical pathways govern fundamental biological control networks; while individual pathways are understood, the combinatorial complexity of the biological control apparatus is too high to be fully understood through "wet" analysis alone.

We are developing innovative software tools that can faithfully simulate the behaviour of biochemical networks, focussing on programmed cell death (apoptosis) and growth factor activated kinase (MAPK). Both networks are at the focus of current drug discovery efforts in important disease areas including cancer, arteriosclerosis, stroke, heart disease, chronic inflammatory and degenerative diseases. The tools we are developing will facilitate basic research by enabling a deeper understanding of the effects of mutations, and applied research by helping to predict drug effects. A strategic aspect of this work is the continuous cross check between modelling and real experimental data.

Maturity: Initial Research
Region: UK
Type: Other
Grant Value:
Start Date: 20/11/2002
End Date: Not specified
Project Status: funded
Funding Agency: DTI

Project Members
Prof Muffy Calder
Prof Keith van Rijsbergen
Prof David Gilbert

Collaborating Organisations
Beatson Institute (University of Glasgow)
Bioinformatics Research Centre (University of Glasgow)
Department of Computing Science (University of Glasgow)
IBM Research

Component(s) Project Develops
This project is not associated with any components at present.

Application Area(s) associated with Project
This project is not associated with any application areas at present.


Last Updated: 22 Jun 12 11:04
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