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Biology of ageing e-science integration and simulation system



Recent advances in biomedical understanding of the ageing process suggest that it is possible to intervene constructively in the mechanisms that cause or contribute to age-related frailty, disability and disease. However, ageing is a highly complex biological process involving interactions between a number of biochemical mechanisms whose effects occur at the molecular, cell, tissue and whole organism levels. Using high throughput techniques large amounts of data regarding ageing cells and tissues have become available recently and will continue to accumulate in the future. It therefore becomes increasingly important to use these data to create powerful and predictive bioinformatics and biomathematical models to explore current ideas about the biochemical mechanisms of the ageing process. The goals of theoretical models are to (i) sharpen understanding of biological processes or hypothesis under consideration. (ii) highlight gaps in current knowledge, and (iii) develop the capacity to make clear, testable predictions. Conventional publication of predictions from models is limited to a few illustrative examples. In contrast, BASIS will be designed to be highly interactive. It aims to engage biologists in selecting and running parameter combinations of their own and becoming fully involved in dialogue about model specification and design. In this way BASIS will encourage and support interaction between biological, bioinformatics, IT and mathematical/statistical science. Such interaction is essential to achieve the full potential of Integrative and Systems Biology.

Maturity: Initial Research
Region: UK
Type: Pilot
Grant Value: £442,000.00
Start Date: 01/05/2002
End Date: 01/05/2006
Project Status: funded
Funding Agency: BBSRC MRC DTI

Project Members
Prof Paul Durham
Prof Tom Kirkwood

Collaborating Organisations
STFC - Daresbury Laboratory
University of Newcastle upon Tyne

Component(s) Project Develops
Application Services
Grid Computational Services
Domain/ Task Ontologies and Metadata

Application Area(s) associated with Project


Last Updated: 22 Jun 12 11:02
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