The essential elements of an Interdisciplinary Research Collaboration (IRC) are a "critical mass" of researchers, a concentration of advanced instrumentation and excellent multi-disciplinary research and training opportunities. IRCs bring together respected researchers from different scientific and technical backgrounds to undertake major, six-year, IT-based research programmes in collaboration with industry. IRCs currently working in e-Science include MIAS, DIRC, AKT and Equator. IRC projects involve one or more of these groups. A current list of IRC projects is given below.
| Collaborative Advanced Knowledge Technologies in the grid. | (CoAKTinG) | |
| Dependability IRC: Dependable, Service-centric Grid Computing | (Dependability IRC) | |
| Environmental e-Science IRC: Linking Environmental e-Science in the lab and in the Field | (Environmental e-Science IRC) | |
| Grid Based Medical Devices for Everday Health | (Medical Devices IRC) | |
| Grid enabled knowledge services: collaborative problem solving environments in medical informatics | (Medical Informatics IRC) | |
| MIAS-Grid. A Medical Image and Signal Research Grid | (MIAS-Grid) |